Across TCGA pan-cancer cohorts, RNU6ATAC7P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU6ATAC7P’s most consistent transcriptional readouts.
The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where RNU6ATAC7P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6ATAC7P is over-expressed in tumor, although a few such as PAAD show the opposite, repressed pattern.
PAAD and KIRC are the cancer types where RNU6ATAC7P tumor–normal differential expression is most reproducible.