Across TCGA pan-cancer cohorts, RNU6ATAC20P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNU6ATAC20P’s most consistent transcriptional readouts.
The strongest signal is observed in esophageal carcinoma (ESCA), where RNU6ATAC20P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6ATAC20P is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
ESCA are the cancer types where RNU6ATAC20P tumor–normal differential expression is most reproducible.