Across TCGA pan-cancer cohorts, RNU6ATAC17P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6ATAC17P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RNU6ATAC17P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6ATAC17P is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.
KIRP, LIHC, and LUAD are the cancer types where RNU6ATAC17P tumor–normal differential expression is most reproducible.