Across TCGA pan-cancer cohorts, RNU6ATAC16P RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RNU6ATAC16P’s most consistent transcriptional readouts.
The strongest signal is observed in rectum adenocarcinoma (READ), where RNU6ATAC16P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6ATAC16P is over-expressed in tumor, although a few such as READ and THCA show the opposite, repressed pattern.
READ, STAD, and THCA are the cancer types where RNU6ATAC16P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6ATAC16P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.