Across TCGA pan-cancer cohorts, RNU6ATAC12P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU6ATAC12P’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6ATAC12P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6ATAC12P is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
LUAD and LUSC are the cancer types where RNU6ATAC12P tumor–normal differential expression is most reproducible.