Across TCGA pan-cancer cohorts, RNU6-945P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-945P’s most consistent transcriptional readouts.
The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RNU6-945P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-945P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
LIHC, KICH, and THCA are the cancer types where RNU6-945P tumor–normal differential expression is most reproducible.