Across TCGA pan-cancer cohorts, RNU6-858P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-858P’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-858P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-858P is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.

HNSC, READ, and UCEC are the cancer types where RNU6-858P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-858P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	II,III,IV	+0.178	.021	4	view →
READ	All	III,IV	+0.685	<.001	2	view →
UCEC	All	All	−0.313	.047	2	view →
PRAD	All	All	+0.172	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNU6-858P RNA expression & survival · all RNU6-858P data types