Across TCGA pan-cancer cohorts, RNU6-831P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU6-831P’s most consistent transcriptional readouts.
The strongest signal is observed in prostate adenocarcinoma (PRAD), where RNU6-831P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-831P is over-expressed in tumor, although a few such as PRAD and KIRC show the opposite, repressed pattern.
PRAD and KIRC are the cancer types where RNU6-831P tumor–normal differential expression is most reproducible.