Across TCGA pan-cancer cohorts, RNU6-813P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-813P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU6-813P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-813P is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.
THCA, BRCA, and KIRC are the cancer types where RNU6-813P tumor–normal differential expression is most reproducible.