Across TCGA pan-cancer cohorts, RNU6-744P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-744P’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RNU6-744P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-744P is over-expressed in tumor.
COAD, PRAD, and KIRP are the cancer types where RNU6-744P tumor–normal differential expression is most reproducible.