RNU6-6P

Across TCGA pan-cancer cohorts, RNU6-6P RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated RNU6-6P data layer.

The strongest signal is observed in mesothelioma (MESO), where higher RNU6-6P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU6-6P expression acts as an unfavorable survival marker, although some lineages such as STAD and CESC show a favorable association.

MESO, KICH, and LUSC are the cancer types where RNU6-6P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.341	0.601	<.001	123	view →
KICH	DFS	Tertile	II,III,IV	0.541	0.902	.004	78	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
LGG	DFS	Median	All	0.665	0.800	<.001	33	view →
STAD	DFS	Quartile	All	0.496	0.310	.003	29	view →
PAAD	OS	Tertile	All	0.363	0.526	.034	18	view →
KIRC	OS	Tertile	II,III,IV	0.406	0.593	.026	18	view →
THCA	OS	Tertile	III,IV	0.291	0.942	.004	18	view →
LIHC	OS	Tertile	All	0.662	0.822	.002	18	view →
CHOL	OS	Tertile	II,III,IV	0.201	0.700	.036	9	view →
COAD	OS	Tertile	All	0.780	0.891	.033	9	view →
CESC	DFS	Tertile	III,IV	0.808	0.530	.034	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

RNU6-6P–MESO (OS)

Open the MESO breakdown →