Across TCGA pan-cancer cohorts, RNU6-606P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-606P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-606P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-606P is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

LUSC, THCA, and KICH are the cancer types where RNU6-606P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-606P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	II,III,IV	−0.329	.005	3	view →
THCA	All	All	−0.171	.005	2	view →
KICH	All	II,III,IV	+0.112	.034	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU6-606P RNA expression & survival · all RNU6-606P data types