Across TCGA pan-cancer cohorts, RNU6-5P RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of RNU6-5P’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-5P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-5P is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.
LUSC, COAD, and BRCA are the cancer types where RNU6-5P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-5P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.