Across TCGA pan-cancer cohorts, RNU6-541P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-541P’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU6-541P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-541P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA, ESCA, and KIRC are the cancer types where RNU6-541P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-541P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.173	.003	4	view →
ESCA	Male	All	+0.650	.044	1	view →
KIRC	All	All	+0.049	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU6-541P RNA expression & survival · all RNU6-541P data types