RNU6-539P

Across TCGA pan-cancer cohorts, RNU6-539P RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated RNU6-539P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RNU6-539P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU6-539P expression acts as an unfavorable survival marker, although some lineages such as BLCA and LUAD show a favorable association.

UVM, THCA, and BLCA are the cancer types where RNU6-539P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	III,IV	0.314	0.903	<.001	69	view →
THCA	DFS	Tertile	III,IV	0.229	0.791	<.001	39	view →
BLCA	OS	Quartile	III,IV	0.654	0.337	.009	30	view →
CHOL	OS	Tertile	II,III,IV	0.315	0.788	.007	18	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	18	view →
LUAD	OS	Tertile	III,IV	0.407	0.233	.020	18	view →
ACC	OS	Tertile	IV	0.327	0.633	.045	18	view →
SARC	OS	Tertile	All	0.919	0.523	.005	15	view →
KICH	DFS	Tertile	IV	0.269	0.784	.045	9	view →
DLBC	OS	Tertile	All	0.646	0.973	.007	9	view →
PAAD	DFS	Tertile	III,IV	0.152	0.821	.045	9	view →
HNSC	OS	Tertile	III,IV	0.355	0.580	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

RNU6-539P–UVM (OS)

Open the UVM breakdown →