Across TCGA pan-cancer cohorts, RNU6-49P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-49P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU6-49P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-49P is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where RNU6-49P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-49P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.097	<.001	5	view →
KICH	All	II,III,IV	−0.160	.044	1	view →
LIHC	Male	II,III,IV	−0.160	.029	1	view →
LUSC	All	All	+0.046	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNU6-49P RNA expression & survival · all RNU6-49P data types