Across TCGA pan-cancer cohorts, RNU6-497P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNU6-497P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU6-497P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-497P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where RNU6-497P tumor–normal differential expression is most reproducible.