Across TCGA pan-cancer cohorts, RNU6-46P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-46P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RNU6-46P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-46P is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and CHOL are the cancer types where RNU6-46P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-46P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	III,IV	−1.160	<.001	6	view →
KICH	All	All	−0.723	<.001	5	view →
CHOL	Female	All	−0.690	<.001	4	view →
KIRC	All	II,III,IV	+0.390	.005	3	view →
THCA	All	All	+0.127	.036	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNU6-46P RNA expression & survival · all RNU6-46P data types