Across TCGA pan-cancer cohorts, RNU6-39P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-39P’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU6-39P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-39P is over-expressed in tumor.

BRCA, LUAD, and HNSC are the cancer types where RNU6-39P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-39P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.165	.025	6	view →
LUAD	Male	All	+0.388	.046	2	view →
HNSC	All	III,IV	+0.086	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU6-39P RNA expression & survival · all RNU6-39P data types