Across TCGA pan-cancer cohorts, RNU6-342P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-342P’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU6-342P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-342P is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

BRCA, THCA, and ESCA are the cancer types where RNU6-342P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-342P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	−0.825	<.001	6	view →
THCA	Female	All	−0.185	<.001	3	view →
ESCA	All	All	+0.261	.024	1	view →
KICH	Female	All	+0.226	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNU6-342P RNA expression & survival · all RNU6-342P data types