RNU6-323P

Across TCGA pan-cancer cohorts, RNU6-323P RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RNU6-323P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-323P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-323P is over-expressed in tumor.

LUSC, BRCA, and BLCA are the cancer types where RNU6-323P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-323P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	II,III,IV	+0.990	<.001	8	view →
BRCA	All	III,IV	+0.515	.003	6	view →
BLCA	All	All	+0.809	.006	5	view →
UCEC	All	III,IV	+0.588	.031	4	view →
COAD	All	II,III,IV	+0.435	.004	4	view →
CHOL	Male	All	+1.291	<.001	2	view →
KICH	All	IV	+0.692	.006	2	view →
HNSC	Male	All	+0.177	.020	2	view →
LIHC	All	All	+0.163	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RNU6-323P–LUSC

Open the LUSC breakdown →