Across TCGA pan-cancer cohorts, RNU6-31P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-31P’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-31P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-31P is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

LUAD, KIRC, and HNSC are the cancer types where RNU6-31P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-31P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.346	.013	2	view →
KIRC	All	All	+0.061	.011	2	view →
HNSC	Male	All	+0.199	.017	1	view →
LUSC	Female	All	−0.127	.039	1	view →
BRCA	All	All	+0.121	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNU6-31P RNA expression & survival · all RNU6-31P data types