Q-omics provides the consensus-scored RNU6-30P profile across patient tissues and cancer cell-line models. RNU6-30P expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, RNU6-30P is differentially expressed in 11, with the highest sampling consensus in LUAD. Additionally, RNU6-30P RNA expression shows 17,420 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UCS, LUAD, and TGCT as cancer lineages where RNU6-30P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNU6-30P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNU6-30P survival associations across molecular data types. RNU6-30P RNA expression shows survival associations in the most cancer types (22). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNU6-30P RNA expression–survival associations across cancer types. High RNU6-30P expression shows unfavorable associations in STAD, LUSC and LIHC, but favorable associations in UCS, THCA and SKCM. The UCS Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .010). Together, the overview and detailed table identify UCS as the clearest survival context for RNU6-30P RNA expression.
This table summarizes RNU6-30P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11. The strongest signals are observed in LUAD for RNA.
This table ranks reproducible tumor–normal expression differences for RNU6-30P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNU6-30P shows lower tumor expression in LUAD, BRCA, LUSC, BLCA and UCEC and higher tumor expression in KIRC. The LUAD box plot shows higher RNU6-30P RNA expression in normal versus tumor tissue (log2 FC = −0.946, t-test p < 0.001).
This table shows molecular features associated with RNU6-30P in patient tissues and cancer cell lines. In patient samples, RNU6-30P shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
