Across TCGA pan-cancer cohorts, RNU6-299P RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of RNU6-299P’s most consistent transcriptional readouts.
The strongest signal is observed in cholangiocarcinoma (CHOL), where RNU6-299P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-299P is over-expressed in tumor.
CHOL and LIHC are the cancer types where RNU6-299P tumor–normal differential expression is most reproducible.