Across TCGA pan-cancer cohorts, RNU6-26P RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of RNU6-26P’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU6-26P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-26P is over-expressed in tumor, although a few such as BRCA and COAD show the opposite, repressed pattern.
HNSC, BRCA, and KIRC are the cancer types where RNU6-26P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-26P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.