Across TCGA pan-cancer cohorts, RNU6-269P RNA is linked to patient survival in 4 of 34 cancer types, making it the most broadly survival-associated RNU6-269P data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher RNU6-269P RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNU6-269P expression acts as an unfavorable survival marker, although some lineages such as BLCA and LGG show a favorable association.

BLCA, STAD, and LUSC are the cancer types where RNU6-269P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	II,III,IV	0.788	0.409	.010	48	view →
STAD	DFS	Tertile	All	0.306	0.721	.004	45	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	39	view →
LGG	OS	Quartile	All	0.891	0.758	.016	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNU6-269P tumor-vs-normal RNA expression · all RNU6-269P data types