Across TCGA pan-cancer cohorts, RNU6-262P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-262P’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where RNU6-262P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-262P is over-expressed in tumor, although a few such as UCEC show the opposite, repressed pattern.
COAD, UCEC, and STAD are the cancer types where RNU6-262P tumor–normal differential expression is most reproducible.