Across TCGA pan-cancer cohorts, RNU6-25P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-25P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU6-25P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-25P is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LUSC, COAD, and BRCA are the cancer types where RNU6-25P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-25P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.254	.003	4	view →
COAD	Female	II,III,IV	−0.321	<.001	2	view →
BRCA	All	III,IV	+0.240	.045	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU6-25P RNA expression & survival · all RNU6-25P data types