Across TCGA pan-cancer cohorts, RNU6-20P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU6-20P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU6-20P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-20P is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where RNU6-20P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-20P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	−0.472	<.001	11	view →
THCA	All	II,III,IV	−0.605	<.001	9	view →
KICH	All	II,III,IV	−0.956	<.001	7	view →
KIRP	All	All	−0.521	.001	4	view →
LIHC	Female	All	−0.253	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNU6-20P RNA expression & survival · all RNU6-20P data types