Across TCGA pan-cancer cohorts, RNU6-173P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-173P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU6-173P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-173P is over-expressed in tumor.
KIRC, HNSC, and LUSC are the cancer types where RNU6-173P tumor–normal differential expression is most reproducible.