RNU6-135P

Across TCGA pan-cancer cohorts, RNU6-135P RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated RNU6-135P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RNU6-135P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU6-135P expression acts as an unfavorable survival marker, although some lineages such as LAML and GBM show a favorable association.

UVM, LAML, and THCA are the cancer types where RNU6-135P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	III,IV	0.055	0.692	<.001	81	view →
LAML	DFS	Median	All	0.540	0.237	.004	26	view →
THCA	OS	Tertile	III,IV	0.540	0.807	.011	21	view →
TGCT	OS	Tertile	II,III,IV	0.670	1.000	.005	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
GBM	OS	Tertile	All	0.548	0.388	.030	9	view →
CHOL	OS	Tertile	All	0.154	0.793	.004	9	view →
STAD	OS	Median	III,IV	0.704	0.532	.007	7	view →
BRCA	OS	Tertile	All	0.319	0.589	.026	6	view →
ESCA	OS	Median	III,IV	0.537	0.316	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RNU6-135P–UVM (DFS)

Open the UVM breakdown →