Across TCGA pan-cancer cohorts, RNU6-107P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-107P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RNU6-107P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-107P is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.
KIRC, COAD, and LUAD are the cancer types where RNU6-107P tumor–normal differential expression is most reproducible.