Across TCGA pan-cancer cohorts, RNU6-1064P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU6-1064P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU6-1064P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU6-1064P is over-expressed in tumor, although a few such as THCA and LIHC show the opposite, repressed pattern.
THCA, LIHC, and STAD are the cancer types where RNU6-1064P tumor–normal differential expression is most reproducible.