Across TCGA pan-cancer cohorts, RNU6-1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU6-1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RNU6-1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU6-1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUAD, LUSC, and BRCA are the cancer types where RNU6-1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU6-1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.551	<.001	8	view →
LUSC	Male	All	+0.292	.004	2	view →
BRCA	All	All	+0.165	.032	2	view →
THCA	All	All	−0.183	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: RNU6-1 RNA expression & survival · all RNU6-1 data types