RNU5F-4P

Across TCGA pan-cancer cohorts, RNU5F-4P RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated RNU5F-4P data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher RNU5F-4P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU5F-4P expression acts as an unfavorable survival marker, although some lineages such as LGG and LUSC show a favorable association.

UVM, COAD, and KIRC are the cancer types where RNU5F-4P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.227	0.768	<.001	108	view →
COAD	OS	Tertile	All	0.235	0.630	<.001	72	view →
KIRC	DFS	Tertile	IV	0.279	0.559	.006	72	view →
MESO	OS	Tertile	All	0.052	0.528	.016	54	view →
THCA	DFS	Tertile	III,IV	0.131	0.637	.006	54	view →
ESCA	OS	Tertile	All	0.489	1.000	.004	43	view →
LGG	DFS	Tertile	All	0.855	0.701	<.001	30	view →
DLBC	DFS	Tertile	II,III,IV	0.433	0.949	.001	24	view →
UCEC	DFS	Tertile	All	0.388	0.672	.004	24	view →
READ	DFS	Tertile	All	0.165	0.573	.012	18	view →
LUAD	DFS	Tertile	IV	0.418	0.748	.020	18	view →
LUSC	OS	Tertile	All	0.856	0.745	.014	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

RNU5F-4P–UVM (DFS)

Open the UVM breakdown →