Across TCGA pan-cancer cohorts, RNU5E-8P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU5E-8P’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU5E-8P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU5E-8P is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

LUSC, LUAD, and BLCA are the cancer types where RNU5E-8P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU5E-8P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	All	−1.140	<.001	8	view →
LUAD	Female	All	−1.128	<.001	7	view →
BLCA	All	All	−0.237	.017	4	view →
BRCA	Female	II,III,IV	−0.056	.043	2	view →
KIRC	All	All	−0.045	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RNU5E-8P RNA expression & survival · all RNU5E-8P data types