RNU5B-6P

Across TCGA pan-cancer cohorts, RNU5B-6P RNA is linked to patient survival in 6 of 34 cancer types, making it the most broadly survival-associated RNU5B-6P data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher RNU5B-6P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU5B-6P expression acts as an unfavorable survival marker.

SKCM, KICH, and BRCA are the cancer types where RNU5B-6P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.269	0.789	<.001	126	view →
KICH	DFS	Tertile	All	0.043	0.971	<.001	90	view →
BRCA	OS	Tertile	All	0.336	0.924	.001	72	view →
HNSC	DFS	Tertile	All	0.161	0.603	.017	45	view →
UCEC	DFS	Tertile	All	0.100	0.646	.024	36	view →
KIRC	DFS	Tertile	IV	0.113	0.649	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RNU5B-6P–SKCM (OS)

Open the SKCM breakdown →