Across TCGA pan-cancer cohorts, RNU5B-1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RNU5B-1 data layer.
The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RNU5B-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU5B-1 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.
ACC, KIRP, and COAD are the cancer types where RNU5B-1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.