RNU5A-4P

Across TCGA pan-cancer cohorts, RNU5A-4P RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated RNU5A-4P data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RNU5A-4P RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU5A-4P expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

LIHC, UVM, and LUSC are the cancer types where RNU5A-4P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.212	0.790	<.001	63	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	54	view →
LUSC	OS	Tertile	IV	0.001	0.673	.014	36	view →
READ	DFS	Tertile	IV	0.183	0.639	.002	36	view →
STAD	DFS	Tertile	IV	0.121	0.462	.009	21	view →
BRCA	DFS	Tertile	III,IV	0.973	0.862	.018	12	view →
CESC	OS	Tertile	All	0.314	0.612	.014	12	view →
PAAD	OS	Tertile	All	0.213	0.500	.017	9	view →
COAD	OS	Tertile	II,III,IV	0.612	0.804	.024	9	view →
ESCA	DFS	Median	All	0.912	0.543	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

RNU5A-4P–LIHC (OS)

Open the LIHC breakdown →