Across TCGA pan-cancer cohorts, RNU5A-1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated RNU5A-1 data layer.
The strongest signal is observed in thyroid carcinoma (THCA), where higher RNU5A-1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RNU5A-1 expression acts as an unfavorable survival marker, although some lineages such as THYM and HNSC show a favorable association.
THCA, CHOL, and KICH are the cancer types where RNU5A-1 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.