Across TCGA pan-cancer cohorts, RNU4ATAC17P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNU4ATAC17P’s most consistent transcriptional readouts.
The strongest signal is observed in lung squamous cell carcinoma (LUSC), where RNU4ATAC17P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4ATAC17P is over-expressed in tumor.
LUSC are the cancer types where RNU4ATAC17P tumor–normal differential expression is most reproducible.