Across TCGA pan-cancer cohorts, RNU4ATAC16P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU4ATAC16P’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where RNU4ATAC16P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4ATAC16P is over-expressed in tumor.
BRCA, BLCA, and LUSC are the cancer types where RNU4ATAC16P tumor–normal differential expression is most reproducible.