Across TCGA pan-cancer cohorts, RNU4ATAC14P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of RNU4ATAC14P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RNU4ATAC14P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU4ATAC14P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where RNU4ATAC14P tumor–normal differential expression is most reproducible.