RNU4ATAC

Across TCGA pan-cancer cohorts, RNU4ATAC RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RNU4ATAC’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RNU4ATAC RNA is repressed in tumor relative to normal tissue. In most cancer types RNU4ATAC is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and COAD are the cancer types where RNU4ATAC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4ATAC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−2.775	<.001	10	view →
KICH	Female	II,III,IV	−1.498	<.001	8	view →
COAD	All	All	+0.747	<.001	7	view →
BRCA	All	III,IV	−0.691	.001	4	view →
LIHC	All	All	+0.324	.003	3	view →
UCEC	All	IV	−1.650	.001	2	view →
CHOL	All	II,III,IV	+1.260	.015	2	view →
KIRP	All	All	−0.332	.003	2	view →
LUSC	Male	III,IV	−1.082	.016	1	view →
ESCA	Male	All	+0.931	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RNU4ATAC–THCA

Open the THCA breakdown →