RNU4-5P

Across TCGA pan-cancer cohorts, RNU4-5P RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RNU4-5P data layer.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher RNU4-5P RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RNU4-5P expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

STAD, HNSC, and UCS are the cancer types where RNU4-5P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Quartile	IV	0.094	0.661	.002	52	view →
HNSC	DFS	Tertile	IV	0.736	0.592	.007	52	view →
UCS	OS	Tertile	II,III,IV	0.790	0.401	.019	48	view →
LAML	DFS	Median	All	0.507	0.239	<.001	40	view →
DLBC	DFS	Median	II,III,IV	0.538	0.913	.004	30	view →
LUAD	DFS	Median	II,III,IV	0.577	0.336	.024	21	view →
PAAD	DFS	Tertile	II,III,IV	0.392	0.186	<.001	19	view →
LUSC	DFS	Median	II,III,IV	0.624	0.860	.007	19	view →
ACC	OS	Median	IV	0.777	0.309	.019	19	view →
SKCM	DFS	Quartile	III,IV	0.120	0.371	.007	13	view →
THCA	OS	Quartile	II,III,IV	0.871	0.973	.010	13	view →
LGG	OS	Median	All	0.869	0.739	.002	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RNU4-5P–STAD (DFS)

Open the STAD breakdown →