Across TCGA pan-cancer cohorts, RNU4-50P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU4-50P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where RNU4-50P RNA is repressed in tumor relative to normal tissue. In most cancer types RNU4-50P is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and LUAD are the cancer types where RNU4-50P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4-50P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.244	.006	6	view →
COAD	All	II,III,IV	−0.113	.007	4	view →
LUAD	Female	All	+0.227	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU4-50P RNA expression & survival · all RNU4-50P data types