Across TCGA pan-cancer cohorts, RNU4-4P RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RNU4-4P’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where RNU4-4P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4-4P is over-expressed in tumor.
STAD, LUSC, and ESCA are the cancer types where RNU4-4P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4-4P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.