Q-omics provides the consensus-scored RNU4-43P profile across patient tissues and cancer cell-line models. RNU4-43P expression is associated with patient survival in 5 of 34 cancer types, with the highest sampling consensus in HNSC. Additionally, RNU4-43P RNA expression shows 5,923 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight HNSC, and STAD as cancer lineages where RNU4-43P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes RNU4-43P survival associations across molecular data types. RNU4-43P RNA expression shows survival associations in the most cancer types (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

RNU4-43P data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	5	HNSC (216)	view →

This table ranks reproducible RNU4-43P RNA expression–survival associations across cancer types. High RNU4-43P expression shows unfavorable associations in HNSC, UCEC, ACC and LGG, but favorable associations in STAD. The HNSC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for RNU4-43P RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.061	0.697	<.001	216	view →
UCEC	OS	Tertile	II,III,IV	0.215	0.771	<.001	108	view →
ACC	OS	Tertile	All	0.169	0.640	.001	51	view →
LGG	DFS	Tertile	All	0.344	0.835	<.001	27	view →
STAD	OS	Tertile	III,IV	0.798	0.592	.038	9	view →

Pink = unfavorable, green = favorable. all 5 lineages →

RNU4-43P-HNSC (DFS)

Kaplan–Meier survival curve for RNU4-43P RNA expression in HNSC: high vs low expression groups.

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Cross-omics associations

This table shows molecular features associated with RNU4-43P in patient tissues and cancer cell lines. In patient samples, RNU4-43P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
Function (RNA)	5,923	STAD (5749)	view →
RNA	3,168	ESCA (1192)	view →