Across TCGA pan-cancer cohorts, RNU4-42P RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RNU4-42P’s most consistent transcriptional readouts.
The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RNU4-42P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4-42P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
HNSC, LUSC, and UCEC are the cancer types where RNU4-42P tumor–normal differential expression is most reproducible.