Across TCGA pan-cancer cohorts, RNU4-40P RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of RNU4-40P’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where RNU4-40P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RNU4-40P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

CHOL, THCA, and KIRC are the cancer types where RNU4-40P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RNU4-40P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	II,III,IV	+0.590	<.001	2	view →
THCA	All	III,IV	−0.209	.025	2	view →
KIRC	All	All	+0.062	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RNU4-40P RNA expression & survival · all RNU4-40P data types